Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.73 |
| ▸ | SMO | Q99835 | 3/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551323 | 0.93 | MAPK14 (0.72) | MAPK14SMOMAPK13MAPK12MAPK11 | |
| SCHEMBL4551331 | 0.93 | MAPK14 (0.71) | MAPK14SMOMAPK13MAPK12MAPK11 | |
| SCHEMBL5490044 | 0.91 | MAPK14 (0.74) | MAPK14SMO | |
| SCHEMBL14534470 | 0.90 | MAPK14 (0.67) | MAPK14SMOMAPK13MAPK12MAPK11 | |
| SCHEMBL5481697 | 0.88 | MAPK14 (0.71) | MAPK14SMOMAPK13MAPK12MAPK11 | |
| SCHEMBL4418530 | 0.88 | MAPK14 (0.61) | MAPK14SMOMAPK13MAPK12MAPK11 | |
| SCHEMBL4551497 | 0.87 | MAPK14 (0.60) | MAPK14SMOMAPK13MAPK12MAPK11 | |
| SCHEMBL5481692 | 0.86 | MAPK14 (0.77) | MAPK14SMOMAPK13MAPK12MAPK11 | |
| SCHEMBL4409060 | 0.86 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL4551653 | 0.85 | DDR2 (0.55) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |