Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15974174 | 0.77 | LMNA (0.63) | PRMT5LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL4537862 | 0.75 | KDM5A (0.56) | PRMT5LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL18925763 | 0.75 | KDM4E (0.44) | PRMT5LMNAGRM5SMN1; SMN2NPC1 | |
| SCHEMBL23888697 | 0.74 | LMNA (0.50) | LMNAGRM5SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4392713 | 0.73 | LOXL2 (0.49) | LMNASMN1; SMN2GLAKMT2AKDM4E | |
| SCHEMBL8008287 | 0.73 | GRM5 (0.56) | LMNAGRM5SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2729506 | 0.73 | GRM5 (0.46) | LMNAGRM5SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4398938 | 0.72 | HRH4 (0.46) | PRMT5SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL22584985 | 0.70 | KDM4E (0.46) | KDM4EMAPK10 | |
| SCHEMBL4411361 | 0.70 | PIK3CA (0.63) | PRMT5NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959951-B1 | HETEROARYL SUBSTITUTED PIPERIDINE DERIVATIVES AS L-CPT1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-12-23 | — | — | EP | disclosed |