Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411769 | 0.79 | F2RL1 (0.40) | RAB9ASCDNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4152975 | 0.72 | KDM4C (0.50) | RAB9ASCDNPC1KMT2AMEN1 | |
| SCHEMBL12467073 | 0.71 | EPHX2 (0.40) | RAB9ASCDNPC1KMT2ASMN1; SMN2 | |
| SCHEMBL15273772 | 0.71 | SCD (0.36) | SCDLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL30445344 | 0.70 | IRAK4 (0.38) | SCD | |
| SCHEMBL4763827 | 0.69 | PARP1 (0.54) | NPC1LMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4167072 | 0.68 | CAPN1 (0.36) | RAB9ASCDLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2528074 | 0.68 | PPARA (0.40) | RAB9ANPC1LMNAKMT2AMEN1 | |
| SCHEMBL13729594 | 0.68 | OPRM1 (0.47) | RAB9AKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3330917 | 0.68 | PARP1 (0.50) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |