Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 7/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14071787 | 1.00 | HCRTR1 (0.42) | HCRTR1HCRTR2LRRK2LMNAADRA2A | |
| SCHEMBL20066433 | 0.94 | HCRTR1 (0.41) | HCRTR1HCRTR2LRRK2LMNAADRA2A | |
| SCHEMBL4406414 | 0.93 | HCRTR1 (0.40) | HCRTR1HCRTR2LRRK2LMNAADRA2A | |
| SCHEMBL29687401 | 0.93 | HCRTR1 (0.40) | HCRTR1HCRTR2LRRK2LMNAADRA2A | |
| SCHEMBL14071841 | 0.93 | HCRTR1 (0.40) | HCRTR1HCRTR2LRRK2LMNAADRA2A | |
| SCHEMBL14477479 | 0.93 | LRRK2 (0.40) | HCRTR1HCRTR2LRRK2FKBP1AADORA2A | |
| SCHEMBL31235869 | 0.93 | LRRK2 (0.40) | HCRTR1HCRTR2LRRK2LMNAADRA2A | |
| SCHEMBL20541621 | 0.92 | HCRTR1 (0.38) | HCRTR1HCRTR2LRRK2LMNAADRA2A | |
| SCHEMBL21840235 | 0.92 | HCRTR1 (0.38) | HCRTR1HCRTR2LRRK2LMNAADRA2A | |
| SCHEMBL29687438 | 0.92 | HCRTR1 (0.38) | HCRTR1HCRTR2LRRK2LMNAADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664049-B1 | SYNTHESIS OF PROTECTED PYRROLOBENZODIAZEPINES | SPIROGEN LTD (GB) | 2009-12-23 | — | — | EP | disclosed |
| US-7429658-B2 | Synthesis of protected pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2008-09-30 | — | — | US | disclosed |
| US-20060264622-A1 | Synthesis of protected pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264622-A1 | Synthesis of protected pyrrolobenzodiazepines | SBDS, DRD2, GRIN2D | HCRTR1 1486/4885HCRTR2 860/4885LRRK2 2829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.