Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.70 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.67 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.67 |
| ▸ | DPP4 | P27487 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CCR9 | P51686 | 1/20 | 0.46 |
| ▸ | TYMS | P04818 | 2/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31061260 | 0.83 | ADORA2A (1.00) | ADORA2AHSPA1APABPC1DPP4AHR | |
| SCHEMBL9566604 | 0.82 | HSPA1A (0.77) | ADORA2AHSPA1APABPC1DPP4CA9 | |
| SCHEMBL13871737 | 0.82 | KMT2A (0.58) | CA9CA12CA1CA2ALDH1A1 | |
| SCHEMBL28489546 | 0.82 | ADORA2A (0.48) | ADORA2AHSPA1APABPC1CA9CA12 | |
| SCHEMBL11513204 | 0.80 | HSPA1A (1.00) | ADORA2AHSPA1APABPC1DPP4CA9 | |
| SCHEMBL31259838 | 0.80 | HSPA1A (1.00) | ADORA2AHSPA1APABPC1DPP4CA9 | |
| SCHEMBL9566623 | 0.80 | HSPA1A (0.73) | ADORA2AHSPA1APABPC1DPP4CA9 | |
| SCHEMBL4409822 | 0.79 | KDM4E (0.58) | ADORA2ACA9CA12CA1CA2 | |
| SCHEMBL9468821 | 0.78 | HSPA1A (0.71) | ADORA2AHSPA1APABPC1DPP4ALDH1A1 | |
| SCHEMBL9468703 | 0.78 | HSPA1A (0.71) | ADORA2AHSPA1APABPC1DPP4TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664027-B1 | SUBSTITUTED 2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND METHODS OF USE | AMGEN INC (US) | 2009-12-30 | — | — | EP | disclosed |
| US-7320992-B2 | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use | AMGEN INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1664027-A1 | SUBSTITUTED 2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005021532-A1 | SUBSTITUTED 2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND METHODS OF USE | AMGEN INC (US) | 2005-03-10 | — | — | WO | disclosed |
| US-20050054670-A1 | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use | AMGEN INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054670-A1 | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use | VHL, DPYD, UGT1A1 | ADORA2A 2020/4885HSPA1A 2414/4885PABPC1 4448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.