Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637609 | 0.81 | CYP2D6 (0.35) | CTSSCTSKTSHRCYP2D6CYP2C19 | |
| SCHEMBL9836697 | 0.75 | TSHR (0.39) | CTSSCTSKTSHRCYP2D6CYP2C19 | |
| SCHEMBL9693068 | 0.74 | ALDH1A1 (0.42) | TSHRCYP2D6CYP2C19HIF1ACHRM1 | |
| SCHEMBL4380430 | 0.72 | MEN1 (0.36) | TSHR | |
| SCHEMBL1815708 | 0.69 | CHRM1 (0.35) | HSPD1BLMHSPE1TSHRCYP2D6 | |
| SCHEMBL1817794 | 0.69 | CHRM1 (0.35) | HSPD1BLMHSPE1TSHRCYP2D6 | |
| SCHEMBL4000812 | 0.69 | CHRM1 (0.35) | HSPD1BLMHSPE1TSHRCYP2D6 | |
| SCHEMBL7703902 | 0.69 | GRM2 (0.34) | CTSSCTSKCYP2D6CYP2C19 | |
| SCHEMBL8164857 | 0.68 | GRM2 (0.32) | CTSSCTSKTSHR | |
| SCHEMBL9710049 | 0.67 | TSHR (0.41) | CTSSCTSKTSHRCHRM1AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2017259-A2 | Preparation of gamma-amino acids having affinity for the alpha-2-delta protein | Pfizer Products Inc. (US) | 2009-01-21 | — | — | EP | disclosed |
| EP-1973867-A1 | PREPARATION OF GAMMA-AMINO ACIDS HAVING AFFINITY FOR THE ALPHA-2-DELTA PROTEIN | Pfizer Products Inc. (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007072159-A1 | PREPARATION OF GAMMA-AMINO ACIDS HAVING AFFINITY FOR THE ALPHA-2-DELTA PROTEIN | PFIZER PRODUCTS INC. (US) | 2007-06-28 | — | — | WO | disclosed |