Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.37 |
| ▸ | PDE4A | P27815 | 4/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16769037 | 0.84 | KDM4E (0.52) | TUBB1KDM4EGAAMAPTPDE4D | |
| SCHEMBL4410377 | 0.79 | KDM4E (0.50) | TUBB1KDM4EGAAMAPTPDE4D | |
| SCHEMBL11933107 | 0.77 | KDM4E (0.46) | TUBB1KDM4EGAAMAPTPDE4D | |
| SCHEMBL24240291 | 0.76 | L3MBTL1 (0.47) | TUBB1KDM4EGAAMAPTL3MBTL1 | |
| SCHEMBL17527769 | 0.75 | L3MBTL1 (0.48) | TUBB1KDM4EGAAMAPTTSHR | |
| SCHEMBL12093640 | 0.75 | TUBB1 (0.49) | TUBB1KDM4EGAAMAPTPDE4D | |
| SCHEMBL9230265 | 0.74 | TUBB1 (0.38) | TUBB1GAAPDE4DMAPK1 | |
| SCHEMBL802723 | 0.71 | HTR2A (0.44) | TUBB1MAPK1KDM1A | |
| SCHEMBL4405598 | 0.71 | ALDH1A1 (0.45) | TUBB1KDM4EGAAMAPTTSHR | |
| SCHEMBL15682029 | 0.71 | PDE4D (0.43) | TUBB1KDM4EGAAMAPTPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549651-B1 | PYRIMIDOPYRIMIDONES AS KINASE INHIBITORS | WARNER LAMBERT CO (US) | 2009-12-23 | — | — | EP | disclosed |