Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5603875 | 0.90 | NAMPT (0.41) | NAMPTCYP2C9TSHRTLR2ALDH1A1 | |
| SCHEMBL4410223 | 0.90 | MAPK14 (0.47) | NAMPTMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5603999 | 0.90 | MAPK14 (0.53) | NAMPTMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4411272 | 0.90 | MAPK14 (0.46) | NAMPTMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4551494 | 0.88 | MAPK14 (0.51) | NAMPTMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4416244 | 0.86 | RAF1 (0.44) | MAPK14BRAFRAF1 | |
| SCHEMBL5593171 | 0.83 | RAB9A (0.51) | NAMPTCYP2C9MAPK14BRAFRAF1 | |
| SCHEMBL4419873 | 0.81 | RAF1 (0.52) | MAPK14BRAFRAF1DDR1DDR2 | |
| SCHEMBL4541475 | 0.81 | RAF1 (0.56) | CYP2C9MAPK14BRAFRAF1 | |
| SCHEMBL4413471 | 0.81 | RAF1 (0.58) | MAPK14BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |