Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 8/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828429 | 0.92 | GABRA2 (0.45) | GABRA2GABRB2MAPTHPGDALDH1A1 | |
| SCHEMBL2829188 | 0.84 | MAPT (0.42) | GABRA2GABRB2MAPTHPGDALDH1A1 | |
| SCHEMBL2831625 | 0.81 | MAPT (0.42) | GABRA2GABRB2MAPTHPGDALDH1A1 | |
| SCHEMBL2834112 | 0.80 | GABRA2 (0.43) | GABRA2GABRB2MAPTHPGDALDH1A1 | |
| SCHEMBL2830711 | 0.78 | HPGD (0.44) | GABRA2GABRB2MAPTHPGDALDH1A1 | |
| SCHEMBL2831822 | 0.76 | MAPT (0.61) | MAPTHPGDALDH1A1TDP1NPSR1 | |
| SCHEMBL2831553 | 0.76 | MAPT (0.40) | GABRA2GABRB2MAPTHPGDALDH1A1 | |
| SCHEMBL2863488 | 0.75 | RORC (0.52) | MAPTHPGDALDH1A1TDP1NPSR1 | |
| SCHEMBL4415348 | 0.74 | GABRA2 (0.40) | GABRA2GABRB2CYP2C9CYP2C19RORC | |
| SCHEMBL980587 | 0.74 | GABRA2 (0.40) | GABRA2GABRB2MAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227538-A1 | N-(Hetero)Aryl Indole Derivatives as Pesticides | NOVARTIS AG (CH) | 2009-09-10 | — | — | US | disclosed |
| EP-1783114-A1 | N-(hetero)aryl indole derivatives as pesticides | Novartis AG (CH) | 2007-05-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227538-A1 | N-(Hetero)Aryl Indole Derivatives as Pesticides | IDO1, IDO2, CHRM1 | GABRA2 1275/4885GABRB2 1625/4885MAPT 3360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.