Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | DDX3X | O00571 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21711070 | 0.88 | KDM5A (0.78) | KDM5AGAAKDM4EMAPTNPSR1 | |
| SCHEMBL13548881 | 0.88 | KDM5A (0.78) | KDM5AGAAKDM4EMAPTNPSR1 | |
| SCHEMBL4415035 | 0.88 | KDM5A (0.78) | KDM5AGAAKDM4EMAPTNPSR1 | |
| SCHEMBL20363503 | 0.86 | KDM5A (0.75) | KDM5AGAAKDM4EMAPTNPSR1 | |
| SCHEMBL14149140 | 0.86 | KDM5A (0.75) | KDM5AGAAKDM4EMAPTNPSR1 | |
| SCHEMBL13548870 | 0.86 | KDM5A (0.75) | KDM5AGAAKDM4EMAPTNPSR1 | |
| SCHEMBL13548892 | 0.86 | KDM5A (0.75) | KDM5AGAAKDM4EMAPTNPSR1 | |
| SCHEMBL20859495 | 0.85 | KDM5A (0.74) | KDM5AGAAKDM4EMAPTNPSR1 | |
| SCHEMBL13548879 | 0.85 | KDM5A (0.74) | KDM5AGAAKDM4EMAPTNPSR1 | |
| SCHEMBL21711181 | 0.84 | KDM5A (0.72) | KDM5AGAAKDM4EMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11839617-B2 | Theramutein modulators | HMI Medical Innovations, LLC (US) | 2023-12-12 | — | — | US | disclosed |
| US-11839617-B2 | Theramutein modulators | HMI Medical Innovations, LLC (US) | 2023-12-12 | — | — | US | disclosed |
| US-11714080-B2 | Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC (US) | 2023-08-01 | — | — | US | disclosed |
| US-11714080-B2 | Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC (US) | 2023-08-01 | — | — | US | disclosed |
| US-11692998-B2 | Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC (US) | 2023-07-04 | — | — | US | disclosed |
| US-11692998-B2 | Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC (US) | 2023-07-04 | — | — | US | disclosed |
| US-20210215671-A1 | COMPOUNDS AND METHODS OF IDENTIFYING, SYNTHESIZING, OPTIMIZING AND PROFILING PROTEIN MODULATORS | HMI Medical Innovations, LLC | 2021-07-15 | — | — | US | disclosed |
| US-20210215670-A1 | COMPOUNDS AND METHODS OF IDENTIFYING, SYNTHESIZING, OPTIMIZING AND PROFILING PROTEIN MODULATORS | HMI Medical Innovations, LLC | 2021-07-15 | — | — | US | disclosed |
| US-10955408-B2 | Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC (US) | 2021-03-23 | — | — | US | disclosed |
| US-20210015825-A1 | THERAMUTEIN MODULATORS | HMI Medical Innovations, LLC | 2021-01-21 | — | — | US | disclosed |
| US-20100016298-A1 | Theramutein modulators | HOUSEY GERAD M | 2010-01-21 | — | — | US | disclosed |
| US-20090275070-A1 | Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators | HOUSEY GERARD M | 2009-11-05 | — | — | US | disclosed |
| US-20090275070-A1 | Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators | HOUSEY GERARD M | 2009-11-05 | — | — | US | disclosed |
| US-20080269262-A1 | Blocking or activation of endogenous proteins variations rncoded by mutated gees | HMI MEDICAL INNOVATIONS, LLC. | 2008-10-30 | — | — | US | disclosed |
| US-20080269262-A1 | Blocking or activation of endogenous proteins variations rncoded by mutated gees | HMI MEDICAL INNOVATIONS, LLC. | 2008-10-30 | — | — | US | disclosed |
| WO-2008091681-A2 | THERAMUTEIN MODULATORS | HOUSEY GERARD M (US) | 2008-07-31 | — | — | WO | disclosed |
| WO-2007062213-A2 | COMPOUNDS AND METHODS OF IDENTIFYING, SYNTHESIZING, OPTIMIZING AND PROFILING PROTEIN MODULATORS | HOUSEY PHARMACEUTICALS INC (US) | 2007-05-31 | — | — | WO | disclosed |
| US-20070111199-A1 | Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC | 2007-05-17 | — | — | US | disclosed |
| US-20070111199-A1 | Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC | 2007-05-17 | — | — | US | disclosed |
| WO-2007037898-A2 | THERAMUTEIN MODULATORS | HOUSEY PHARMACEUTICALS INC (US) | 2007-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016298-A1 | Theramutein modulators | TSG101, SERPINE1, PLAUR | KDM5A 4434/4885GAA 3394/4885KDM4E 4221/4885 |
| US-20210015825-A1 | THERAMUTEIN MODULATORS | TSG101, SERPINE1, PLAUR | KDM5A 4434/4885GAA 3394/4885KDM4E 4221/4885 |
| US-11839617-B2 | Theramutein modulators | TSG101, SERPINE1, PLAUR | KDM5A 4434/4885GAA 3394/4885KDM4E 4221/4885 |
| US-20080269262-A1 | Blocking or activation of endogenous proteins variations rncoded by mutated gees | SERBP1, SERPINA6, UBE2V1 | KDM5A 3794/4885GAA 2927/4885KDM4E 4172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.