Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRE | P78334 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412507 | 0.91 | PDE2A (0.49) | PDE2AGABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL4632901 | 0.90 | PDE2A (0.39) | PDE2AGABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL4410792 | 0.87 | GABRA1 (0.56) | PDE2AGABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL4412511 | 0.85 | GABRA1 (0.54) | PDE2AGABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL5038997 | 0.84 | PDE2A (0.66) | PDE2AGABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL4410609 | 0.84 | PDE2A (0.44) | PDE2AGABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL4422075 | 0.83 | GABRA1 (0.53) | PDE2AGABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL4410830 | 0.82 | GABRA1 (0.54) | PDE2AGABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL4418612 | 0.81 | PDE2A (0.46) | PDE2AGABRA1GABRA5GABRA2GABRA3 | |
| SCHEMBL4413427 | 0.80 | GABRA1 (0.48) | PDE2AGABRA1GABRA5GABRA2GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215752-A1 | Compounds, preparation and therapeutic use thereof | BAY CITY CAPITAL LLC | 2009-08-27 | — | — | US | claimed |
| EP-1749824-A1 | Benzodiazepine derivatives, their preparation and the therapeutic use thereof | NEURO3D (FR) | 2007-02-07 | — | — | EP | claimed |
| US-20090215752-A1 | Compounds, preparation and therapeutic use thereof | BAY CITY CAPITAL LLC | 2009-08-27 | — | — | US | disclosed |
| EP-1749824-A1 | Benzodiazepine derivatives, their preparation and the therapeutic use thereof | NEURO3D (FR) | 2007-02-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215752-A1 | Compounds, preparation and therapeutic use thereof | PDE12, PDE4B, PDE2A | PDE2A 3/4885GABRA1 60/4885GABRA5 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.