SCHEMBL4632901

SCHEMBL4632901

CCN1C(=O)CN=C(c2cccc(C#CCOC)c2)c2c1cc(OC)c(-c1ccccc1)c2OC

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE2A O00408 1/20 0.39
TP53 P04637 2/20 0.36
MAPT P10636 1/20 0.36
HDAC1 Q13547 3/20 0.36
GABRA1 P14867 3/20 0.35
GABRG2 P18507 3/20 0.35
GABRB3 P28472 3/20 0.35
GABRA5 P31644 3/20 0.35
GABRA3 P34903 3/20 0.35
GABRA2 P47869 3/20 0.35
PTGDR2 Q9Y5Y4 5/20 0.35
HDAC6 Q9UBN7 2/20 0.35
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
KDM4E B2RXH2 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
TSHR P16473 2/20 0.33
GABRB2 P47870 1/20 0.33
GAA P10253 1/20 0.33
USP2 O75604 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4411571 0.90 PDE2A (0.47) PDE2AHDAC1GABRA1GABRG2GABRB3
SCHEMBL4413377 0.88 GABRA1 (0.45) PDE2ATP53MAPTGABRA1GABRG2
SCHEMBL4424399 0.81 PDE2A (0.60) PDE2ATP53MAPTPTGDR2MEN1
SCHEMBL4412507 0.81 PDE2A (0.49) PDE2AHDAC1GABRA1GABRG2GABRB3
SCHEMBL4410915 0.81 GABRA1 (0.46) PDE2ATP53MAPTGABRA1GABRG2
SCHEMBL4410796 0.79 PTGDR2 (0.47) PDE2ATP53GABRA1GABRG2GABRB3
SCHEMBL4412817 0.78 GABRA1 (0.43) PDE2ATP53MAPTHDAC1GABRA1
SCHEMBL4708427 0.78 PDE2A (0.42) PDE2ATP53MAPTHDAC1GABRA1
SCHEMBL5493792 0.78 PDE2A (0.48) PDE2ATP53MAPTHDAC1GABRA1
SCHEMBL4410766 0.78 GABRA1 (0.42) PDE2ATP53MAPTGABRA1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1910315-A2 BENZODIAZEPINE DERIVATIVES, THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF NEURO3D (FR) 2008-04-16 EP disclosed
WO-2007026254-A2 BENZODIAZEPINE DERIVATIVES , THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF NEURO3D (FR) 2007-03-08 WO disclosed