Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 4/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867433 | 0.84 | TNF (0.43) | TNFPLA2G7LMNA | |
| SCHEMBL7006492 | 0.82 | TNF (0.40) | TDP1TNFPLA2G7LMNA | |
| SCHEMBL4425565 | 0.82 | TNF (0.40) | TDP1TNFPLA2G7LMNA | |
| SCHEMBL7012983 | 0.79 | EP300 (0.40) | TNFPLA2G7LMNA | |
| SCHEMBL4415720 | 0.75 | PLA2G7 (0.62) | PLA2G7 | |
| SCHEMBL7099070 | 0.75 | TNF (0.41) | TNFPLA2G7LMNA | |
| SCHEMBL4416303 | 0.74 | POLB (0.51) | L3MBTL1ABL1RIN1TDP1AKT1 | |
| SCHEMBL7093582 | 0.70 | KMT2A (0.42) | L3MBTL1TDP1POLBRAB9APLA2G7 | |
| SCHEMBL7009479 | 0.70 | PLA2G7 (0.40) | TDP1GAAPLA2G7 | |
| SCHEMBL6946487 | 0.70 | KMT2A (0.38) | TDP1GAAPLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |