Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 13/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006492 | 0.87 | TNF (0.40) | TNFLMNAPLA2G7KMT2ATDP1 | |
| SCHEMBL5867433 | 0.84 | TNF (0.43) | TNFLMNAPLA2G7 | |
| SCHEMBL7012983 | 0.83 | EP300 (0.40) | TNFLMNAPLA2G7 | |
| SCHEMBL4411686 | 0.82 | L3MBTL1 (0.41) | TNFLMNAPLA2G7TDP1 | |
| SCHEMBL7099070 | 0.80 | TNF (0.41) | TNFLMNAPLA2G7 | |
| SCHEMBL7093582 | 0.74 | KMT2A (0.42) | LMNAPLA2G7KMT2ATDP1 | |
| SCHEMBL4414205 | 0.71 | PLA2G7 (0.72) | PLA2G7 | |
| SCHEMBL4425561 | 0.71 | TNF (0.40) | TNFLMNA | |
| SCHEMBL6133131 | 0.70 | CYP4F2 (0.51) | LMNAKMT2A | |
| SCHEMBL7009479 | 0.69 | PLA2G7 (0.40) | PLA2G7KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |
| EP-1173424-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000066566-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |