Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 10/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.38 |
| ▸ | PGR | P06401 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4439311 | 0.80 | NR3C1 (0.43) | NR3C1NR3C2PGRMEN1KMT2A | |
| SCHEMBL4440438 | 0.80 | NR3C1 (0.41) | NR3C1NR3C2PGRMEN1KMT2A | |
| SCHEMBL4439332 | 0.79 | NR3C1 (0.43) | NR3C1NR3C2PGRMEN1KMT2A | |
| SCHEMBL3217669 | 0.79 | NR3C1 (0.61) | NR3C1NR3C2PGR | |
| SCHEMBL4441125 | 0.79 | NR3C2 (0.44) | NR3C1NR3C2PGRMEN1KMT2A | |
| SCHEMBL4438774 | 0.78 | NR3C1 (0.52) | NR3C1NR3C2PGRMEN1KMT2A | |
| SCHEMBL4439342 | 0.76 | NR3C1 (0.39) | NR3C1NR3C2PGRMEN1KMT2A | |
| SCHEMBL4442338 | 0.75 | NR3C1 (0.42) | NR3C1NR3C2PGRMEN1KMT2A | |
| SCHEMBL4438023 | 0.75 | NR3C1 (0.38) | NR3C1NR3C2PGRMEN1KMT2A | |
| SCHEMBL4442284 | 0.74 | MEN1 (0.40) | NR3C1NR3C2PGRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136634-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124665-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-10-16 | — | — | WO | disclosed |