Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 7/20 | 0.40 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | NPY4R | P50391 | 3/20 | 0.33 |
| ▸ | NPY1R | P25929 | 2/20 | 0.33 |
| ▸ | NPY2R | P49146 | 2/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | GGT1 | P19440 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1263209 | 0.97 | FOLH1 (0.39) | FOLH1C3AR1NOD1ITGB3ITGA2B | |
| SCHEMBL61231 | 0.97 | FOLH1 (0.39) | FOLH1C3AR1NOD1ITGB3ITGA2B | |
| SCHEMBL1419574 | 0.92 | FOLH1 (0.44) | FOLH1NOD1TLR2ALOX15SIRT6 | |
| SCHEMBL27675576 | 0.92 | FOLH1 (0.44) | FOLH1NOD1TLR2ALOX15SIRT6 | |
| SCHEMBL11950325 | 0.88 | NPY4R (0.36) | FOLH1NPY4RNPY1RNPY2RNPY5R | |
| SCHEMBL16383647 | 0.88 | NPY4R (0.36) | FOLH1NPY4RNPY1RNPY2RNPY5R | |
| SCHEMBL350197 | 0.86 | NOD1 (0.41) | FOLH1C3AR1NOD1ITGB3ITGA2B | |
| SCHEMBL350198 | 0.86 | NOD1 (0.41) | FOLH1C3AR1NOD1ITGB3ITGA2B | |
| SCHEMBL5605498 | 0.86 | FOLH1 (0.38) | FOLH1C3AR1NOD1ITGB3ITGA2B | |
| Dodecanoate SCHEMBL28478322 | 0.85 | NOD1 (0.46) | NOD1TLR2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298747-A1 | Methods and Compositions For Treatment of Nitric Oxide-Induced Clinical Conditions | BIO HOLDING, INC. (US) | 2009-12-03 | — | — | US | claimed |
| US-6864086-B2 | Nitric oxide-scavenging system for culturing oocytes, embryos, or other cells | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2005-03-08 | — | — | US | claimed |
| US-20040220242-A1 | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions | BIO HOLDING, INC. | 2004-11-04 | — | — | US | claimed |
| US-20040220113-A1 | Inhibitors of serine protease activity methods and compositions for treatment of nitric oxide-induced clinical conditions | BIO HOLDING, INC. | 2004-11-04 | — | — | US | claimed |
| WO-2000051623-A2 | INHIBITORS OF SERINE PROTEASE ACTIVITY, METHODS AND COMPOSITIONS FOR TREATMENT OF NITRIC OXIDE-INDUCED CLINICAL CONDITIONS | THE TRUSTEES OF UNIVERSITY TECHNOLOGY CORPORATION (US) | 2000-09-08 | — | — | WO | claimed |
| US-20090298747-A1 | Methods and Compositions For Treatment of Nitric Oxide-Induced Clinical Conditions | BIO HOLDING, INC. (US) | 2009-12-03 | — | — | US | disclosed |
| US-20070224671-A1 | Inhibitors of serine protease activity methods and compositions for treatment of nitric oxide-induced clinical conditions | BIO HOLDING, INC. | 2007-09-27 | — | — | US | disclosed |
| US-6864086-B2 | Nitric oxide-scavenging system for culturing oocytes, embryos, or other cells | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2005-03-08 | — | — | US | disclosed |
| US-20040220113-A1 | Inhibitors of serine protease activity methods and compositions for treatment of nitric oxide-induced clinical conditions | BIO HOLDING, INC. | 2004-11-04 | — | — | US | disclosed |
| US-20040220242-A1 | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions | BIO HOLDING, INC. | 2004-11-04 | — | — | US | disclosed |
| US-20030068816-A1 | Nitric oxide-scavenging system for culturing oocytes, embryos, or other cells | HANSEL WILLIAM (US) | 2003-04-10 | — | — | US | disclosed |
| US-6489308-B1 | ONE AGENT EXHIBITING MAMMALIAN ALPHA 1-ANTITRYPSIN OR ALPHA 1-ANTITRYPSIN-LIKE ACTIVITY, AND A FREE RADICAL SCAVENGER SUCH AS 2,6,8-TRIHYDROXYPURINE, DIHYDRORHODAMINE, OR A COMBINATION THEREOF | TRUSTEES OF UNIVERSITY OF TECHNOLOGY CORPORATION | 2002-12-03 | — | — | US | disclosed |
| US-6426219-B2 | CULTURE CONTAINS A NITRIC OXIDE INHIBITOR SUCH AS FREE HEMOGLOBIN | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE | 2002-07-30 | — | — | US | disclosed |
| US-20010034060-A1 | Nitric oxide-scavenging system for culturing oocytes, embryos, or other cells | HANSEL WILLIAM (US) | 2001-10-25 | — | — | US | disclosed |
| US-6255109-B1 | CULTURING MAMMALIAN OOCYTES OR EMBRYOS IN A CO-CULTURE SYSTEM IN THE PRESENCE OF HEMOGLOBIN, A NITRIC OXIDE INHIBITOR; PROMOTING THE MAINTENANCE, GROWTH AND DEVELOPMENT OF CELLS AND ELIMINATES TOXIC EFFECTS OF NITRIC OXIDE | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE | 2001-07-03 | — | — | US | disclosed |
| WO-2000051623-A2 | INHIBITORS OF SERINE PROTEASE ACTIVITY, METHODS AND COMPOSITIONS FOR TREATMENT OF NITRIC OXIDE-INDUCED CLINICAL CONDITIONS | THE TRUSTEES OF UNIVERSITY TECHNOLOGY CORPORATION (US) | 2000-09-08 | — | — | WO | disclosed |