Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 9/20 | 0.42 |
| ▸ | RXRB | P28702 | 4/20 | 0.42 |
| ▸ | RXRG | P48443 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | RARA | P10276 | 7/20 | 0.41 |
| ▸ | RARB | P10826 | 7/20 | 0.41 |
| ▸ | RARG | P13631 | 7/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412255 | 1.00 | HAO1 (0.43) | HAO1RXRARXRBRXRGCYP1A2 | |
| SCHEMBL4171073 | 0.89 | RXRA (0.36) | HAO1RXRARXRBRXRGCYP1A2 | |
| SCHEMBL4171067 | 0.89 | RXRA (0.36) | HAO1RXRARXRBRXRGCYP1A2 | |
| SCHEMBL4168915 | 0.85 | RXRA (0.39) | HAO1RXRARXRBRXRGCYP1A2 | |
| SCHEMBL4168920 | 0.85 | RXRA (0.39) | HAO1RXRARXRBRXRGCYP1A2 | |
| SCHEMBL4410963 | 0.82 | HAO1 (0.42) | HAO1RXRARXRBRXRGCYP1A2 | |
| SCHEMBL4410959 | 0.82 | HAO1 (0.42) | HAO1RXRARXRBRXRGCYP1A2 | |
| SCHEMBL4175931 | 0.82 | RARA (0.44) | HAO1RXRARXRBRXRGCYP1A2 | |
| SCHEMBL4175933 | 0.82 | RARA (0.44) | HAO1RXRARXRBRXRGCYP1A2 | |
| SCHEMBL4183366 | 0.81 | CYP1A2 (0.46) | HAO1RXRARXRBRXRGCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076124-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008131368-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. (US) | 2008-10-30 | — | — | WO | disclosed |