Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.52 |
| ▸ | MEN1 | O00255 | 9/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | WNT3A | P56704 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13570206 | 0.92 | HDAC1 (0.49) | KMT2AMEN1RAB9AWNT3AABL1 | |
| SCHEMBL4412791 | 0.86 | TRPA1 (0.46) | KMT2AWNT3AABL1RORC | |
| SCHEMBL2443035 | 0.81 | MAPT (0.49) | KMT2ARAB9AABL1 | |
| SCHEMBL15580544 | 0.81 | TRPA1 (0.50) | KMT2AMEN1RAB9AWNT3AABL1 | |
| SCHEMBL613256 | 0.79 | KMT2A (0.48) | KMT2AMEN1RAB9AWNT3A | |
| SCHEMBL2450859 | 0.79 | TRPA1 (0.48) | KMT2AMEN1RAB9AABL1NPC1 | |
| SCHEMBL13570250 | 0.79 | TRPA1 (0.46) | KMT2AMEN1RAB9AWNT3AABL1 | |
| SCHEMBL480355 | 0.79 | TRPA1 (0.60) | KMT2AMEN1RAB9AABL1 | |
| SCHEMBL2440259 | 0.79 | TRPA1 (0.49) | KMT2AMEN1RAB9AABL1 | |
| SCHEMBL610617 | 0.79 | TRPA1 (0.60) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |