Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 8/20 | 0.35 |
| ▸ | HTR2C | P28335 | 6/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405216 | 0.93 | CCNT1 (0.38) | KCNN4HTR2CDRD2HTR2AHRH1 | |
| SCHEMBL4403806 | 0.84 | GRM1 (0.35) | KCNN4HRH1CCNT1CDK9 | |
| SCHEMBL988571 | 0.84 | GRM5 (0.43) | KCNN4CDK9 | |
| SCHEMBL987273 | 0.83 | KCNN4 (0.35) | KCNN4KCNH2CHRNB4CHRNA3CCNT1 | |
| SCHEMBL4407741 | 0.83 | KCNN4 (0.34) | KCNN4HTR2CDRD2CCNT1CDK9 | |
| SCHEMBL985675 | 0.81 | CCNT1 (0.37) | KCNN4HRH1CCNT1CDK9 | |
| SCHEMBL988378 | 0.81 | ERN1 (0.40) | KCNN4HRH1CCNT1CDK9 | |
| SCHEMBL982752 | 0.80 | GRM1 (0.39) | KCNN4HRH1CCNT1CDK9 | |
| SCHEMBL2076538 | 0.80 | GRM5 (0.51) | CCNT1CDK9 | |
| SCHEMBL986695 | 0.79 | NAMPT (0.41) | KCNN4HRH1CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004625-B1 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMA (US) | 2009-12-30 | — | — | EP | claimed |