SCHEMBL4412419

SCHEMBL4412419

CCNC(=O)c1cc(C(C)(C)C)cc(NC(=O)C(=O)c2ccc(-c3ccc(NC)nc3)c3ccccc23)c1OC

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 12/20 0.59
SCARB1 Q8WTV0 8/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1899221 0.89 MAPK14 (0.62) MAPK14SCARB1
SCHEMBL4420018 0.88 MAPK14 (0.60) MAPK14SCARB1
SCHEMBL4943425 0.84 MAPK14 (0.82) MAPK14SCARB1
SCHEMBL4418756 0.84 MAPK14 (0.67) MAPK14SCARB1
SCHEMBL1600228 0.83 MAPK14 (0.57) MAPK14SCARB1
SCHEMBL5312935 0.81 MAPK14 (0.57) MAPK14SCARB1
SCHEMBL12669850 0.76 MAPK14 (0.74) MAPK14SCARB1
SCHEMBL4952957 0.75 MAPK14 (0.83) MAPK14SCARB1
SCHEMBL4416952 0.75 MAPK14 (0.65) MAPK14SCARB1
SCHEMBL1599123 0.74 MAPK14 (0.82) MAPK14SCARB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006091862-A2 CYTOKINE INHIBITORS AND THEIR USE IN THERAPY KEMIA, INC. (US) 2006-08-31 WO claimed
WO-2011063076-A1 METHODS OF TREATING HEPATITIS C VIRUS WITH OXOACETAMIDE COMPOUNDS ITHERX PHARMACEUTICALS, INC. (US) 2011-05-26 WO disclosed
US-20110117055-A1 Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds BRS - TUSTIN SAFEGUARD ASSOCIATES II, LLC 2011-05-19 US disclosed
EP-2035005-A2 THERAPY USING CYTOKINE INHIBITORS Kemia, INC. (US) 2009-03-18 EP disclosed
WO-2007146712-A2 THERAPY USING CYTOKINE INHIBITORS KEMIA, INC. (US) 2007-12-21 WO disclosed
WO-2007058990-A2 THERAPY USING CYTOKINE INHIBITORS KEMIA, INC. (US) 2007-05-24 WO disclosed
WO-2006091862-A2 CYTOKINE INHIBITORS AND THEIR USE IN THERAPY KEMIA, INC. (US) 2006-08-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110117055-A1 Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds OAT, HAVCR2, OTC MAPK14 3352/4885SCARB1 922/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.