Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 7/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.36 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL987033 | 0.83 | CDK9 (0.39) | KCNN4MAPK1 | |
| SCHEMBL985354 | 0.81 | KCNN4 (0.39) | KCNN4MAPK1 | |
| SCHEMBL985890 | 0.79 | PDE4B (0.42) | KCNN4MAPK1 | |
| SCHEMBL986262 | 0.78 | NAMPT (0.41) | KCNN4 | |
| SCHEMBL985146 | 0.77 | PDE4B (0.43) | KCNN4RAB9AMAPK1 | |
| SCHEMBL985145 | 0.77 | PDE4B (0.43) | KCNN4RAB9AMAPK1 | |
| SCHEMBL2074816 | 0.77 | SCN9A (0.38) | KCNN4 | |
| SCHEMBL2074815 | 0.77 | SCN9A (0.38) | KCNN4 | |
| SCHEMBL985129 | 0.76 | KCNN4 (0.42) | KCNN4 | |
| SCHEMBL4404520 | 0.76 | KCNN4 (0.36) | KCNN4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004625-B1 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMA (US) | 2009-12-30 | — | — | EP | claimed |