Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR1F | P30939 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | PARL | Q9H300 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424529 | 0.83 | HTR6 (0.44) | HTR6LMNAPOLB | |
| SCHEMBL1156194 | 0.81 | HTR6 (0.44) | HTR6LMNASMN1; SMN2PARLAKR1C3 | |
| SCHEMBL1156184 | 0.80 | HTR6 (0.47) | HTR6LMNASMN1; SMN2HTR1ADRD2 | |
| SCHEMBL1156624 | 0.79 | CHRM5 (0.43) | HTR6LMNASMN1; SMN2AKR1C3AKR1C1 | |
| SCHEMBL4411754 | 0.77 | CHRM5 (0.42) | HTR6LMNASMN1; SMN2AKR1C3AKR1C1 | |
| SCHEMBL1156547 | 0.76 | HTR6 (0.45) | HTR6LMNASMN1; SMN2HTR1ADRD2 | |
| SCHEMBL1156621 | 0.75 | HTR2C (0.42) | HTR6LMNASMN1; SMN2HTR1ADRD2 | |
| SCHEMBL4411752 | 0.73 | HTR2C (0.41) | HTR6LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL1156550 | 0.73 | GAA (0.44) | HTR6AKR1C3AKR1C1GAAMEN1 | |
| SCHEMBL29065520 | 0.72 | HTR6 (0.47) | HTR6LMNASMN1; SMN2PARLAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |