Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412573 | 0.83 | HTR6 (0.40) | HTR6LMNAPOLB | |
| SCHEMBL2407643 | 0.79 | CHRM5 (0.42) | HTR6METPKMALDH1A1 | |
| SCHEMBL2415052 | 0.79 | MEP1B (0.43) | HTR6METCYP3A4PKMALDH1A1 | |
| SCHEMBL4999257 | 0.79 | CHRM5 (0.50) | HTR6PKMALDH1A1 | |
| SCHEMBL28715560 | 0.79 | HTR6 (0.49) | HTR6METCYP3A4LMNAPKM | |
| SCHEMBL4424525 | 0.79 | MET (0.44) | HTR6METCYP3A4LMNAPKM | |
| SCHEMBL4999263 | 0.78 | AKR1C3 (0.44) | HTR6CYP3A4ALDH1A1 | |
| SCHEMBL28702913 | 0.77 | MET (0.46) | HTR6METCYP3A4LMNAPKM | |
| SCHEMBL28713092 | 0.71 | KDM4E (0.38) | HTR6METMAPK1ALDH1A1 | |
| SCHEMBL28936708 | 0.71 | KDM4E (0.40) | HTR6METMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |