SCHEMBL4412952

SCHEMBL4412952

CC(c1cn[nH]c1)c1cn(CC(=O)NCc2ccc(-c3ccc(F)cc3)cc2)c(SCc2ccc(F)cc2)nc1=O

nearest known ligand 0.58

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 20/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4426036 0.96 PLA2G7 (0.64) PLA2G7
SCHEMBL4424701 0.95 PLA2G7 (0.53) PLA2G7
SCHEMBL4423073 0.91 PLA2G7 (0.63) PLA2G7
SCHEMBL4415599 0.88 PLA2G7 (0.65) PLA2G7
SCHEMBL5867356 0.85 PLA2G7 (0.62) PLA2G7
SCHEMBL7579290 0.83 PLA2G7 (0.58) PLA2G7
SCHEMBL4411626 0.82 PLA2G7 (0.64) PLA2G7
SCHEMBL4415703 0.82 PLA2G7 (0.64) PLA2G7
SCHEMBL4419833 0.82 PLA2G7 (0.62) PLA2G7
SCHEMBL4415554 0.81 PLA2G7 (0.65) PLA2G7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1479671-B1 Pyrimidinone compounds SMITHKLINE BEECHAM PLC (GB) 2009-05-27 EP disclosed