Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 16/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 16/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823722 | 0.89 | NPC1 (0.46) | MAP4K4TYRO3 | |
| SCHEMBL4413005 | 0.88 | TLR8 (0.46) | MAP4K4TLR7TLR8 | |
| SCHEMBL823602 | 0.83 | PRMT6 (0.41) | MAP4K4TYRO3 | |
| SCHEMBL823715 | 0.77 | TLR8 (0.43) | TLR7TLR8 | |
| SCHEMBL823619 | 0.76 | TLR8 (0.40) | TLR7TLR8 | |
| SCHEMBL823723 | 0.76 | NPC1 (0.41) | TLR7TLR8 | |
| SCHEMBL4531314 | 0.76 | TLR8 (0.53) | TLR7TLR8 | |
| SCHEMBL823727 | 0.76 | TLR8 (0.39) | TLR7TLR8 | |
| SCHEMBL823766 | 0.76 | SYK (0.37) | TLR7TLR8 | |
| SCHEMBL823774 | 0.75 | MKNK1 (0.43) | MAP4K4TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090324543-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC (US) | 2009-12-31 | — | — | US | claimed |
| US-20090324543-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090324543-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | PNPO, DPYD, PLPBP | MAP4K4 2930/4885TLR7 1598/4885TLR8 2236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.