Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 4/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.33 |
| ▸ | SRC | P12931 | 4/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4420763 | 0.88 | WEE1 (0.38) | WEE1ABL1FGFR1SRCPTK2 | |
| SCHEMBL4417439 | 0.75 | AURKA (0.39) | WEE1ABL1FGFR1SRCPTK2 | |
| SCHEMBL4414678 | 0.71 | FGFR1 (0.53) | WEE1ABL1FGFR1SRCPTK2 | |
| SCHEMBL4411774 | 0.71 | MAPK10 (0.36) | ABL1FGFR1SRCPTK2MAPK8 | |
| SCHEMBL4411476 | 0.70 | CDK1 (0.33) | WEE1ABL1FGFR1SRCPTK2 | |
| SCHEMBL4423212 | 0.66 | CNR2 (0.39) | ABL1FGFR1PTK2MAPK8MAPK9 | |
| SCHEMBL4413502 | 0.66 | CDK1 (0.36) | WEE1ABL1FGFR1SRCPTK2 | |
| SCHEMBL4420761 | 0.66 | PKMYT1 (0.40) | WEE1ABL1FGFR1SRCPTK2 | |
| SCHEMBL4413304 | 0.65 | IKBKB (0.49) | PTK2AURKAAURKBDCLK1CDK1 | |
| SCHEMBL4423148 | 0.65 | RIPK2 (0.49) | WEE1ABL1FGFR1SRCPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615921-B1 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | claimed |