Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.39 |
| ▸ | CDK1 | P06493 | 6/20 | 0.39 |
| ▸ | CDK2 | P24941 | 6/20 | 0.39 |
| ▸ | KDR | P35968 | 6/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 5/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.39 |
| ▸ | LCK | P06239 | 5/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.39 |
| ▸ | GSK3A | P49840 | 5/20 | 0.39 |
| ▸ | GSK3B | P49841 | 5/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 5/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.39 |
| ▸ | PRKCG | P05129 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417446 | 0.88 | AURKA (0.40) | AURKAAURKBCDK5CDK1CDK2 | |
| SCHEMBL28548935 | 0.85 | AURKA (0.41) | AURKAAURKBCDK5CDK1CDK2 | |
| SCHEMBL4413220 | 0.83 | CDK1 (0.40) | AURKAAURKBCDK5CDK1CDK2 | |
| SCHEMBL4413502 | 0.80 | CDK1 (0.36) | AURKAAURKBCDK5CDK1CDK2 | |
| SCHEMBL4423148 | 0.76 | RIPK2 (0.49) | AURKAAURKBCDK5CDK1CDK2 | |
| SCHEMBL4413413 | 0.75 | WEE1 (0.37) | AURKAAURKBCDK5CDK1CDK2 | |
| SCHEMBL4411476 | 0.74 | CDK1 (0.33) | AURKAAURKBCDK5CDK1CDK2 | |
| SCHEMBL4414385 | 0.74 | CYP2C19 (0.41) | AURKAAURKBCDK5CDK1CDK2 | |
| SCHEMBL4414678 | 0.74 | FGFR1 (0.53) | AURKBKDRMAP4K4LCKFGFR1 | |
| SCHEMBL4416334 | 0.74 | IKBKB (0.42) | CDK1CDK2KDRSYKPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615921-B1 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | claimed |