Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 7/20 | 0.33 |
| ▸ | KDR | P35968 | 7/20 | 0.33 |
| ▸ | CDK2 | P24941 | 6/20 | 0.33 |
| ▸ | AURKA | O14965 | 5/20 | 0.33 |
| ▸ | DCLK1 | O15075 | 5/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.33 |
| ▸ | TYK2 | P29597 | 5/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.33 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.33 |
| ▸ | PRKCG | P05129 | 4/20 | 0.33 |
| ▸ | LCK | P06239 | 4/20 | 0.33 |
| ▸ | FYN | P06241 | 4/20 | 0.33 |
| ▸ | LYN | P07948 | 4/20 | 0.33 |
| ▸ | RET | P07949 | 4/20 | 0.33 |
| ▸ | IGF1R | P08069 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411774 | 0.84 | MAPK10 (0.36) | CDK1KDRCDK2AURKAAURKB | |
| SCHEMBL4413438 | 0.79 | MAPK10 (0.34) | CDK2FGFR1IGF1RSRCMAPK9 | |
| SCHEMBL4423212 | 0.79 | CNR2 (0.39) | KDRAURKAAURKBFGFR1JAK2 | |
| SCHEMBL4417073 | 0.79 | WEE1 (0.41) | CDK1KDRCDK2FGFR1IGF1R | |
| SCHEMBL4413502 | 0.78 | CDK1 (0.36) | CDK1KDRCDK2AURKADCLK1 | |
| SCHEMBL4416334 | 0.76 | IKBKB (0.42) | CDK1KDRCDK2SYKABL1 | |
| SCHEMBL4424495 | 0.76 | MET (0.34) | FGFR1ALKGSK3AWEE1EGFR | |
| SCHEMBL4415084 | 0.75 | MAPK10 (0.36) | CDK2FGFR1JAK2SRCMAPK9 | |
| SCHEMBL4412920 | 0.75 | MAPK10 (0.36) | CDK2FGFR1IGF1RSRCMAPK9 | |
| SCHEMBL4413555 | 0.75 | BRAF (0.38) | CDK2FGFR1SRCSYKMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615921-B1 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | claimed |