Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.41 |
| ▸ | CHAT | P28329 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4169512 | 1.00 | TAAR1 (0.46) | TAAR1AHRHDAC4MEF2DCHAT | |
| SCHEMBL4169517 | 1.00 | TAAR1 (0.46) | TAAR1AHRHDAC4MEF2DCHAT | |
| SCHEMBL4175681 | 0.89 | TAAR1 (0.56) | TAAR1CHATRELAGRIN1GRIN2B | |
| SCHEMBL4175683 | 0.89 | TAAR1 (0.56) | TAAR1CHATRELAGRIN1GRIN2B | |
| SCHEMBL4172616 | 0.83 | TAAR1 (0.41) | TAAR1PLAUMAOA | |
| SCHEMBL4172611 | 0.83 | TAAR1 (0.41) | TAAR1PLAUMAOA | |
| SCHEMBL4168931 | 0.81 | RELA (0.58) | TAAR1AHRRELANFE2L2CYP19A1 | |
| SCHEMBL4168924 | 0.81 | RELA (0.58) | TAAR1AHRRELANFE2L2CYP19A1 | |
| SCHEMBL4412735 | 0.80 | TAAR1 (0.45) | TAAR1HDAC4MEF2DPLAUNFE2L2 | |
| SCHEMBL4412729 | 0.80 | TAAR1 (0.45) | TAAR1HDAC4MEF2DPLAUNFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076124-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008131368-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. (US) | 2008-10-30 | — | — | WO | disclosed |