Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 5/20 | 0.34 |
| ▸ | DRD5 | P21918 | 5/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.34 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3178194 | 0.92 | DRD1 (0.38) | MAPK14DRD1DRD5ADORA3ADORA2A | |
| SCHEMBL3178189 | 0.92 | DRD1 (0.38) | MAPK14DRD1DRD5ADORA3ADORA2A | |
| SCHEMBL4506393 | 0.83 | PIK3CD (0.38) | MAPK14DRD1DRD5HKDC1SMN1; SMN2 | |
| SCHEMBL3179574 | 0.82 | DRD1 (0.44) | DRD1DRD5SMN1; SMN2PIK3CDPIK3CA | |
| SCHEMBL3179577 | 0.82 | DRD1 (0.44) | DRD1DRD5SMN1; SMN2PIK3CDPIK3CA | |
| SCHEMBL4791118 | 0.80 | TRPV4 (0.35) | PIK3CDPIK3CAPIK3CGPDE4APDE4B | |
| SCHEMBL3169024 | 0.80 | CTSS (0.36) | DRD1DRD5 | |
| SCHEMBL3169031 | 0.80 | CTSS (0.36) | DRD1DRD5 | |
| SCHEMBL3177134 | 0.79 | CDK1 (0.38) | DRD1DRD5SMN1; SMN2TSHRPDE4A | |
| SCHEMBL3177139 | 0.79 | CDK1 (0.38) | DRD1DRD5SMN1; SMN2TSHRPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009121036-A2 | SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-10-01 | — | — | WO | disclosed |