Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4407836 | 0.93 | NR1H4 (0.45) | RXFP1HTTLMNAALDH1A1NR1H4 | |
| SCHEMBL4417707 | 0.92 | CYP3A4 (0.43) | NAMPTHTTL3MBTL1LMNAMAPK1 | |
| SCHEMBL5593328 | 0.91 | RXFP1 (0.43) | RXFP1HTTALDH1A1NR1H4PPARG | |
| SCHEMBL5592971 | 0.90 | RXFP1 (0.42) | RXFP1HTTSMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL5604346 | 0.88 | HTT (0.42) | NAMPTHTTL3MBTL1LMNAMAPK1 | |
| SCHEMBL5592986 | 0.88 | RXFP1 (0.41) | RXFP1HTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4551631 | 0.88 | GRM4 (0.49) | RXFP1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL5616375 | 0.87 | MAPT (0.48) | HTTLMNAMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4412543 | 0.83 | ALDH1A1 (0.42) | NAMPTKCNMA1RXFP1HTTLMNA | |
| SCHEMBL4419761 | 0.82 | CYP1A2 (0.49) | NAMPTHTTL3MBTL1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |