Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.47 |
| ▸ | SMO | Q99835 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 7/20 | 0.38 |
| ▸ | BRAF | P15056 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4408497 | 0.99 | MAPK14 (0.48) | MAPK14SMOTDP1NPC1RAF1 | |
| SCHEMBL4407770 | 0.94 | MAPK14 (0.51) | MAPK14SMORAF1BRAF | |
| SCHEMBL4414281 | 0.89 | MAPK14 (0.58) | MAPK14SMONPC1RAF1BRAF | |
| SCHEMBL4416214 | 0.88 | MAPK14 (0.43) | MAPK14NPC1RAF1BRAF | |
| SCHEMBL4408184 | 0.87 | MAPK14 (0.56) | MAPK14SMORAF1BRAFLYN | |
| SCHEMBL4418552 | 0.87 | MAPK14 (0.44) | MAPK14NPC1RAF1BRAF | |
| SCHEMBL4409531 | 0.86 | RAF1 (0.42) | RAF1BRAF | |
| SCHEMBL5604132 | 0.85 | TEK (0.45) | MAPK14NPC1RAF1BRAFKDM4E | |
| SCHEMBL4409551 | 0.85 | RAF1 (0.43) | RAF1BRAF | |
| SCHEMBL5593352 | 0.84 | RAF1 (0.41) | MAPK14NPC1RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |