Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | TEK | Q02763 | 6/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4416214 | 0.99 | MAPK14 (0.43) | MAPK14TEKDHODHBRAFRAF1 | |
| SCHEMBL4408316 | 0.95 | MAPK14 (0.49) | MAPK14BRAFRAF1NAMPTTP53 | |
| SCHEMBL4410223 | 0.89 | MAPK14 (0.47) | MAPK14TEKDHODHBRAFRAF1 | |
| SCHEMBL4411272 | 0.89 | MAPK14 (0.46) | MAPK14TEKDHODHBRAFRAF1 | |
| SCHEMBL4408497 | 0.88 | MAPK14 (0.48) | MAPK14BRAFRAF1NPC1 | |
| SCHEMBL4419873 | 0.88 | RAF1 (0.52) | MAPK14TEKBRAFRAF1 | |
| SCHEMBL4415069 | 0.87 | MAPK14 (0.47) | MAPK14BRAFRAF1NPC1 | |
| SCHEMBL4412830 | 0.87 | RAF1 (0.52) | MAPK14TEKBRAFRAF1 | |
| SCHEMBL5593016 | 0.86 | TEK (0.53) | TEKBRAFNAMPTNPC1ALDH1A1 | |
| SCHEMBL4409551 | 0.86 | RAF1 (0.43) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |