Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 12/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | TGM1 | P22735 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1003663 | 0.91 | PARP1 (0.46) | PARP1GPR119HSD11B1HDAC1HTR3A | |
| SCHEMBL1005642 | 0.79 | HTR3A (0.45) | PARP1GPR119HTR3A | |
| SCHEMBL1005641 | 0.79 | HTR3A (0.45) | PARP1GPR119HTR3A | |
| SCHEMBL1003480 | 0.79 | ABCB1 (0.44) | PARP1GPR119HTR3A | |
| SCHEMBL1004366 | 0.79 | ABCB1 (0.44) | PARP1GPR119HTR3A | |
| SCHEMBL1005752 | 0.78 | NAAA (0.49) | GPR119HDAC1HTR3AKCNH2 | |
| SCHEMBL1006345 | 0.77 | NR1H3 (0.53) | HTR3AKCNH2 | |
| SCHEMBL1006343 | 0.77 | NR1H3 (0.53) | HTR3AKCNH2 | |
| SCHEMBL1005424 | 0.77 | HTR3A (0.47) | PARP1GPR119HTR3AKCNH2 | |
| SCHEMBL1003499 | 0.77 | HTR3A (0.47) | PARP1GPR119HTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061460-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | Albany Molecular Research, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008019372-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-02-14 | — | — | WO | disclosed |