SCHEMBL4416375

SCHEMBL4416375

C[S+]([O-])c1c(F)cc(-c2noc(COC3CCN(C(=O)OC(C)(C)C)CC3)n2)cc1F

nearest known ligand 0.67

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 14/20 0.67
HDAC6 Q9UBN7 3/20 0.43
HDAC4 P56524 4/20 0.42
DPP4 P27487 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4413016 0.89 GPR119 (0.66) GPR119HDAC6HDAC4
SCHEMBL4415733 0.86 GPR119 (0.69) GPR119HDAC6HDAC4DPP4
SCHEMBL4420165 0.85 GPR119 (0.68) GPR119HDAC6HDAC4
SCHEMBL4422093 0.85 GPR119 (0.75) GPR119HDAC6HDAC4
SCHEMBL4415855 0.85 GPR119 (0.69) GPR119HDAC6HDAC4
SCHEMBL4423367 0.84 GPR119 (0.61) GPR119HDAC6HDAC4DPP4
SCHEMBL4415852 0.84 GPR119 (0.70) GPR119HDAC4
SCHEMBL4422316 0.84 GPR119 (0.70) GPR119HDAC6HDAC4DPP4
SCHEMBL4422346 0.83 GPR119 (0.67) GPR119HDAC6HDAC4
SCHEMBL4422209 0.83 GPR119 (0.67) GPR119HDAC6HDAC4DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090325924-A1 GPCR Agonists PROSIDION LIMITED (GB) 2009-12-31 US disclosed
US-20090325924-A1 GPCR Agonists PROSIDION LIMITED (GB) 2009-12-31 US disclosed
US-20090325924-A1 GPCR Agonists PROSIDION LIMITED (GB) 2009-12-31 US disclosed
WO-2007003960-A1 GPCR AGONISTS PROSIDION LIMITED (GB) 2007-01-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090325924-A1 GPCR Agonists GPR119, GCGR, GPR27 GPR119 1/4885HDAC6 2609/4885HDAC4 2550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.