SCHEMBL4416417

SCHEMBL4416417

CCNC(=O)c1ccc(-c2nc(COC3CCN(C(=O)OC(C)(C)C)CC3)no2)cc1

nearest known ligand 0.55

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 7/20 0.55
HDAC4 P56524 3/20 0.48
KDM4E B2RXH2 1/20 0.46
PKM P14618 1/20 0.46
HDAC6 Q9UBN7 2/20 0.45
KMT2A Q03164 1/20 0.43
CETP P11597 2/20 0.42
SPHK2 Q9NRA0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4422145 0.93 GPR119 (0.52) GPR119HDAC4KDM4EPKMHDAC6
SCHEMBL13598276 0.92 SPHK2 (0.53) GPR119HDAC4KDM4EPKMHDAC6
SCHEMBL4416490 0.92 GPR119 (0.52) GPR119HDAC4KDM4EPKMHDAC6
SCHEMBL4412788 0.91 GPR119 (0.55) GPR119HDAC4KDM4EPKMHDAC6
SCHEMBL13598272 0.91 GPR119 (0.51) GPR119HDAC4KDM4EPKMHDAC6
SCHEMBL4414097 0.90 GPR119 (0.52) GPR119HDAC4KDM4EPKMHDAC6
SCHEMBL13598280 0.90 GPR119 (0.51) GPR119HDAC4KDM4EPKMHDAC6
SCHEMBL13598273 0.90 GPR119 (0.51) GPR119HDAC4KDM4EPKMHDAC6
SCHEMBL4419139 0.90 GPR119 (0.54) GPR119HDAC4KDM4EPKMHDAC6
SCHEMBL4415710 0.89 GPR119 (0.50) GPR119HDAC4KDM4EPKMHDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090325924-A1 GPCR Agonists PROSIDION LIMITED (GB) 2009-12-31 US disclosed
US-20090325924-A1 GPCR Agonists PROSIDION LIMITED (GB) 2009-12-31 US disclosed
US-20090325924-A1 GPCR Agonists PROSIDION LIMITED (GB) 2009-12-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090325924-A1 GPCR Agonists GPR119, GCGR, GPR27 GPR119 1/4885HDAC4 2550/4885KDM4E 3925/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.