Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAT1 | P18440 | 7/20 | 1.00 |
| ▸ | CA2 | P00918 | 1/20 | 1.00 |
| ▸ | EPHX1 | P07099 | 1/20 | 1.00 |
| ▸ | MMP3 | P08254 | 2/20 | 0.75 |
| ▸ | MMP13 | P45452 | 2/20 | 0.75 |
| ▸ | PIM1 | P11309 | 2/20 | 0.71 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.71 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.71 |
| ▸ | CISD1 | Q9NZ45 | 4/20 | 0.71 |
| ▸ | MYC | P01106 | 2/20 | 0.71 |
| ▸ | MAOA | P21397 | 1/20 | 0.71 |
| ▸ | MAX | P61244 | 1/20 | 0.71 |
| ▸ | IL1RN | P18510 | 1/20 | 0.69 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1812224 | 1.00 | NAT1 (1.00) | NAT1CA2EPHX1MMP3MMP13 | |
| SCHEMBL3491175 | 1.00 | NAT1 (1.00) | NAT1CA2EPHX1MMP3MMP13 | |
| SCHEMBL1247510 | 0.90 | NAT1 (1.00) | NAT1CA2EPHX1MMP3MMP13 | |
| SCHEMBL10596480 | 0.90 | NAT1 (1.00) | NAT1CA2EPHX1MMP3MMP13 | |
| SCHEMBL1247509 | 0.90 | NAT1 (1.00) | NAT1CA2EPHX1MMP3MMP13 | |
| SCHEMBL8173568 | 0.86 | NAT1 (0.75) | NAT1CA2EPHX1MMP3MMP13 | |
| SCHEMBL18103088 | 0.86 | MMP3 (1.00) | NAT1CA2EPHX1MMP3MMP13 | |
| SCHEMBL18102890 | 0.86 | NAT1 (0.76) | NAT1CA2EPHX1MMP3MMP13 | |
| SCHEMBL8173565 | 0.86 | NAT1 (0.75) | NAT1CA2EPHX1MMP3MMP13 | |
| SCHEMBL19991267 | 0.86 | NAT1 (0.76) | NAT1CA2EPHX1MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654380-A4 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR MODULATING HEPARANASE ACTIVATION AND USES THEREOF | INSIGHT BIOPHARMACEUTICALS LTD (IL) | 2009-09-09 | — | — | EP | disclosed |
| US-RE40603-E1 | Silver halide photographic light-sensitive material | FUJIFILM CORPORATION (JP) | 2008-12-09 | — | — | US | disclosed |
| US-20080051445-A1 | 2-Thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways | NATIONAL INSTITUTE OF IMMUNOLOGY. | 2008-02-28 | — | — | US | disclosed |
| EP-1834642-A2 | 2-thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways | National Institute of Immunology (IN) | 2007-09-19 | — | — | EP | disclosed |
| EP-1654380-A2 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR MODULATING HEPARANASE ACTIVATION AND USES THEREOF | Insight Biopharmaceuticals Ltd. (IL) | 2006-05-10 | — | — | EP | disclosed |
| US-6911303-B2 | Light-sensitive silver halide grain | FUJI PHOTO FILM, CO., LTD. (JP) | 2005-06-28 | — | — | US | disclosed |
| WO-2005016227-A2 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR MODULATING HEPARANASE ACTIVATION AND USES THEREOF | INSIGHT BIOPHARMACEUTICALS LTD. (IL) | 2005-02-24 | — | — | WO | disclosed |
| US-20050042213-A1 | Methods and pharmaceutical compositions for modulating heparanase activation and uses thereof | INSIGHT BIOPHARMACEUTICALS LTD. | 2005-02-24 | — | — | US | disclosed |
| US-6723496-B2 | COMPLEX | FUJI PHOTO FILM CO., LTD. (JP) | 2004-04-20 | — | — | US | disclosed |
| US-20030186179-A1 | Light-sensitive silver halide grain | FUJI PHOTO FILM CO., LTD. | 2003-10-02 | — | — | US | disclosed |
| US-5457106-A | Antiinflammatory agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-10-10 | — | — | US | disclosed |
| EP-0659883-A2 | Protein p140 and DNA encoding it | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-06-28 | — | — | EP | disclosed |
| EP-0658802-A2 | Surface latent image type photographic material containing silver halide grains doped with cyano-chromium-complex ion | FUJI PHOTO FILM CO., LTD. (JP) | 1995-06-21 | — | — | EP | disclosed |
| US-5389658-A | Administering as antipyretic, antiinflammatory, analgesic, antiallergic, or immunosupressive agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0612729-A2 | Pyridine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1994-08-31 | — | — | EP | disclosed |
| US-5266457-A | Phosphine sulfide as sensitizer | FUJI PHOTO FILM CO., LTD. (JP) | 1993-11-30 | — | — | US | disclosed |
| US-5246948-A | Antiinflammatory, antipyretic, analgesic, antiallergic, immunosupressing or immunomodulating activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-09-21 | — | — | US | disclosed |
| EP-0522606-A2 | Pyridine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-13 | — | — | EP | disclosed |
| US-4018891-A | INHIBITORS OF ANTIGEN-ANTIBODY REACTIONS | RICHARDSON-MERRELL INC. (US) | 1977-04-19 | — | — | US | disclosed |
| US-3960892-A | ANTIGEN-ANTIBODY REACTION INHIBITION | RICHARDSON-MERRELL INC. (US) | 1976-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050042213-A1 | Methods and pharmaceutical compositions for modulating heparanase activation and uses thereof | HPSE, HPN, ENGASE | NAT1 1754/4885CA2 777/4885EPHX1 382/4885 |
| US-20080051445-A1 | 2-Thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways | FASN, FADS2, TECR | NAT1 77/4885CA2 3072/4885EPHX1 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.