Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.52 |
| ▸ | VEGFA | P15692 | 1/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | STS | P08842 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412360 | 0.85 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTNPSR1ACKR3VEGFA | |
| SCHEMBL32667348 | 0.84 | VEGFA (0.64) | SMN1; SMN2HTTNPSR1VEGFAEGLN1 | |
| SCHEMBL5536182 | 0.80 | VEGFA (0.68) | SMN1; SMN2HTTNPSR1VEGFAEGLN1 | |
| SCHEMBL22771220 | 0.80 | VEGFA (0.49) | SMN1; SMN2HTTNPSR1ACKR3VEGFA | |
| SCHEMBL4424517 | 0.78 | CNR1 (0.52) | SMN1; SMN2KMT2AMEN1DRD2 | |
| SCHEMBL8263259 | 0.78 | ACKR3 (0.52) | SMN1; SMN2HTTNPSR1ACKR3KMT2A | |
| SCHEMBL3979358 | 0.77 | KDM4E (0.57) | SMN1; SMN2HTTNPSR1VEGFAEGLN1 | |
| SCHEMBL12332378 | 0.77 | DPP7 (0.59) | SMN1; SMN2KMT2ADRD2 | |
| SCHEMBL4419042 | 0.76 | DPP7 (0.64) | SMN1; SMN2KMT2A | |
| SCHEMBL5264888 | 0.75 | DPP7 (0.48) | SMN1; SMN2HTTNPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |