Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL853069 | 0.90 | FOLH1 (0.57) | FOLH1HPGDLMNASMN1; SMN2NPC1 | |
| SCHEMBL854248 | 0.89 | FOLH1 (0.59) | FOLH1HPGDLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6809837 | 0.88 | FOLH1 (0.54) | FOLH1HPGDLMNAALDH1A1HTT | |
| SCHEMBL27820729 | 0.87 | FOLH1 (0.56) | FOLH1HPGDLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8070829 | 0.87 | FOLH1 (0.53) | FOLH1HPGDLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL11563262 | 0.86 | MAOB (0.56) | FOLH1HPGDLMNASMN1; SMN2NPC1 | |
| SCHEMBL11565369 | 0.86 | LRRK2 (0.59) | FOLH1HPGDLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL1646582 | 0.84 | RXRA (0.56) | FOLH1HPGDLMNASMN1; SMN2NPC1 | |
| SCHEMBL6680832 | 0.84 | HPGD (0.51) | FOLH1HPGDLMNASMN1; SMN2NPC1 | |
| SCHEMBL5431545 | 0.84 | LRRK2 (0.63) | FOLH1HPGDLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299354-B1 | FACTOR VIIA INHIBITORY (THIO)UREA DERIVATIVES, THEIR PREPARATION AND THEIR USE | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-07-22 | — | — | EP | claimed |
| EP-1299354-B1 | FACTOR VIIA INHIBITORY (THIO)UREA DERIVATIVES, THEIR PREPARATION AND THEIR USE | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-07-22 | — | — | EP | disclosed |