SCHEMBL441671

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL461269	0.92	HDAC8 (0.85)	HDAC8PYGLPYGMHDAC1HDAC6
	SCHEMBL445525	0.89	HDAC8 (1.00)	HDAC8HDAC1HDAC6
	SCHEMBL445401	0.86	HDAC8 (1.00)	HDAC8HDAC1HDAC6MEN1KMT2A
	SCHEMBL444288	0.83	HDAC8 (1.00)	HDAC8HDAC1HDAC6MEN1KMT2A
	SCHEMBL443998	0.79	HDAC8 (1.00)	HDAC8HDAC1HDAC6MEN1KMT2A
	SCHEMBL444916	0.79	HDAC8 (1.00)	HDAC8HDAC1HDAC6TAS1R3TAS1R2
	SCHEMBL444811	0.76	HDAC8 (1.00)	HDAC8HDAC6
	SCHEMBL460449	0.75	HDAC8 (0.60)	HDAC8HDAC1HDAC6
	SCHEMBL443507	0.74	HDAC8 (1.00)	HDAC8HDAC6
	SCHEMBL15906531	0.73	HDAC8 (0.63)	HDAC8HDAC1HDAC6MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.