Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 9/20 | 0.41 |
| ▸ | RAF1 | P04049 | 9/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551763 | 0.94 | MAPK14 (0.39) | MAPK14PLAUBRAFRAF1MAPK13 | |
| SCHEMBL5495529 | 0.93 | MAPK14 (0.39) | MAPK14PLAUBRAFRAF1MAPK13 | |
| SCHEMBL5488042 | 0.91 | MAPK14 (0.44) | MAPK14PLAUBRAFRAF1MAPK13 | |
| SCHEMBL4552259 | 0.87 | MAPK14 (0.48) | MAPK14PLAUBRAFRAF1MAPK13 | |
| SCHEMBL4551483 | 0.86 | MAPK14 (0.39) | MAPK14PLAUBRAFRAF1MAPK13 | |
| SCHEMBL4551537 | 0.86 | MAPK14 (0.39) | MAPK14PLAUBRAFRAF1MAPK13 | |
| SCHEMBL5490107 | 0.85 | MAPK14 (0.39) | MAPK14BRAFRAF1 | |
| SCHEMBL4551762 | 0.84 | RPS6KA3 (0.35) | — | |
| SCHEMBL4551889 | 0.84 | MAPK14 (0.39) | MAPK14PLAUBRAFRAF1MAPK13 | |
| SCHEMBL5494098 | 0.84 | CRHR1 (0.42) | MAPK14PLAUBRAFRAF1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |