Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.61 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412970 | 0.86 | EGFR (0.56) | EGFRFGFR4PIK3CDPIK3CASCN9A | |
| SCHEMBL4412557 | 0.84 | EGFR (0.61) | EGFRFGFR4PIK3CDPIK3CALTA4H | |
| SCHEMBL4147243 | 0.81 | EGFR (0.60) | EGFRFGFR4PIK3CDPIK3CA | |
| SCHEMBL4412993 | 0.79 | EGFR (0.55) | EGFRFGFR4HTTPIK3CDPIK3CA | |
| SCHEMBL28292972 | 0.78 | PIK3CA (0.61) | EGFRFGFR4PIK3CDPIK3CA | |
| SCHEMBL27399910 | 0.77 | EGFR (0.65) | EGFRFGFR4PIK3CDPIK3CA | |
| Formaldehyde SCHEMBL28252166 | 0.76 | EGFR (0.55) | EGFRFGFR4PIK3CDPIK3CA | |
| SCHEMBL3372138 | 0.76 | EGFR (1.00) | EGFRFGFR4PIK3CDPIK3CA | |
| SCHEMBL13837704 | 0.75 | EGFR (0.73) | EGFRPIK3CDPIK3CA | |
| Hydrochloric Acid SCHEMBL28032872 | 0.75 | EGFR (0.96) | EGFRFGFR4PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41065-E1 | Alkynl and azido-substituted 4-anilinoquinazolines | PFIZER, INC. (US) | 2009-12-29 | — | — | US | disclosed |