Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.38 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417418 | 0.79 | EGFR (0.61) | EGFRHTTFGFR4PIK3CDPIK3CA | |
| SCHEMBL4412970 | 0.78 | EGFR (0.56) | EGFRABL1MAP4K4FGFR4PIK3CD | |
| SCHEMBL24125011 | 0.74 | NOTUM (0.46) | EGFRALDH1A1KCNH2SCN5ASCN9A | |
| SCHEMBL4412557 | 0.73 | EGFR (0.61) | EGFRABL1FGFR4PIK3CDPIK3CA | |
| SCHEMBL5074400 | 0.72 | EGFR (0.56) | EGFRABL1FGFR4PIK3CDPIK3CA | |
| SCHEMBL27399910 | 0.72 | EGFR (0.65) | EGFRFGFR4PIK3CDPIK3CAAR | |
| SCHEMBL3372138 | 0.72 | EGFR (1.00) | EGFRALDH1A1FGFR4PIK3CDPIK3CA | |
| SCHEMBL4418182 | 0.70 | EGFR (0.47) | EGFRALDH1A1HTTMAP4K4FGFR4 | |
| Hydrochloric Acid SCHEMBL28032872 | 0.70 | EGFR (0.96) | EGFRALDH1A1FGFR4PIK3CDPIK3CA | |
| SCHEMBL7176453 | 0.70 | DPP4 (0.53) | ALDH1A1HTTKCNH2SCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41065-E1 | Alkynl and azido-substituted 4-anilinoquinazolines | PFIZER, INC. (US) | 2009-12-29 | — | — | US | disclosed |