Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.59 |
| ▸ | RAF1 | P04049 | 5/20 | 0.56 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 5/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413422 | 0.99 | MAPK14 (0.59) | MAPK14RAF1HSPB1LYNLCK | |
| SCHEMBL4420764 | 0.94 | BRAF (0.61) | MAPK14RAF1HSPB1BRAFMAPK13 | |
| SCHEMBL5604341 | 0.87 | MAPK14 (0.43) | MAPK14RAF1HSPB1LYNLCK | |
| SCHEMBL4417865 | 0.84 | BRAF (0.47) | MAPK14RAF1BRAF | |
| SCHEMBL4410286 | 0.83 | RAF1 (0.49) | MAPK14RAF1BRAFCSF1R | |
| SCHEMBL4410231 | 0.83 | BRAF (0.48) | MAPK14RAF1BRAF | |
| SCHEMBL5593431 | 0.82 | RAF1 (0.49) | MAPK14RAF1BRAFCSF1R | |
| SCHEMBL14473010 | 0.82 | RAF1 (0.45) | MAPK14RAF1BRAFCSF1R | |
| SCHEMBL4412866 | 0.82 | RAF1 (0.56) | RAF1LYNBRAFCSF1R | |
| SCHEMBL4409531 | 0.82 | RAF1 (0.42) | RAF1BRAFCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |