Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.47 |
| ▸ | RAF1 | P04049 | 13/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4410231 | 0.99 | BRAF (0.48) | BRAFRAF1MEN1NPC1TP53 | |
| SCHEMBL4551383 | 0.94 | BRAF (0.54) | BRAFRAF1 | |
| SCHEMBL4410286 | 0.88 | RAF1 (0.49) | BRAFRAF1MAPK14 | |
| SCHEMBL14473010 | 0.87 | RAF1 (0.45) | BRAFRAF1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5593431 | 0.87 | RAF1 (0.49) | BRAFRAF1MAPK14 | |
| SCHEMBL4412866 | 0.87 | RAF1 (0.56) | BRAFRAF1 | |
| SCHEMBL5601764 | 0.86 | BRAF (0.40) | BRAFRAF1 | |
| SCHEMBL4409531 | 0.86 | RAF1 (0.42) | BRAFRAF1 | |
| SCHEMBL4420730 | 0.86 | RAB9A (0.50) | BRAFRAF1MEN1NPC1MAPT | |
| SCHEMBL4417023 | 0.86 | RAF1 (0.56) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |