Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.35 |
| ▸ | CA2 | P00918 | 5/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | DRD5 | P21918 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL780030 | 0.78 | CA1 (0.56) | CA1CA2CA9CXCR2CXCR1 | |
| SCHEMBL8821206 | 0.78 | CA1 (0.56) | CA1CA2CA9CXCR2CXCR1 | |
| SCHEMBL1404374 | 0.77 | CISD1 (0.35) | CA1CA2CA9KMT2A | |
| SCHEMBL2767385 | 0.77 | CA2 (0.57) | CA1CA2CA9 | |
| SCHEMBL2287643 | 0.77 | ALDH1A1 (0.35) | CA1CA2CA9DRD2DRD3 | |
| SCHEMBL4600112 | 0.76 | TDP1 (0.51) | CA1CA2CA9KMT2A | |
| SCHEMBL499083 | 0.76 | CXCR2 (0.41) | CA1CA2CA9CXCR2CXCR1 | |
| SCHEMBL28807949 | 0.76 | CA1 (0.54) | CA1CA2CA9CXCR2CXCR1 | |
| Iodide SCHEMBL3347577 | 0.76 | CA1 (0.54) | CA1CA2CA9CXCR2CXCR1 | |
| SCHEMBL1128833 | 0.76 | CA1 (0.54) | CA1CA2CA9CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776336-B1 | 2-PHENYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE PHA R MA SPA RES & MFG (IT) | 2009-09-30 | — | — | EP | claimed |
| CN-100372831-C | Sulfonic acids, derivatives thereof and pharmaceutical compositions containing them | DOMPE SPA (IT) | 2008-03-05 | — | — | CN | claimed |
| CN-1882530-A | Amidines and derivatives thereof and pharmaceutical compositions containing them | DOMPE PHA R MA SPA RES & MFG (IT) | 2006-12-20 | — | — | CN | claimed |
| CN-1761645-A | Sulfonic acids, their derivatives and pharmaceutical compositions containing them | DOMPE SPA (IT) | 2006-04-19 | — | — | CN | claimed |
| CN-117440940-A | Material for photoelectric conversion element for image pickup element and photoelectric conversion element for image pickup element | 东曹株式会社 | 2024-01-23 | — | — | CN | disclosed |
| CN-100372831-C | Sulfonic acids, derivatives thereof and pharmaceutical compositions containing them | DOMPE SPA (IT) | 2008-03-05 | — | — | CN | disclosed |
| CN-1882530-A | Amidines and derivatives thereof and pharmaceutical compositions containing them | DOMPE PHA R MA SPA RES & MFG (IT) | 2006-12-20 | — | — | CN | disclosed |
| CN-1761645-A | Sulfonic acids, their derivatives and pharmaceutical compositions containing them | DOMPE SPA (IT) | 2006-04-19 | — | — | CN | disclosed |
| US-6943189-B2 | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG CO-A reductase inhibitors | G.D. SEARLE & CO. (US) | 2005-09-13 | — | — | US | disclosed |
| US-6784201-B2 | FOR PROPHYLAXIS AND TREATMENT OF HYPERLIPIDEMIC CONDITIONS SUCH AS THOSE ASSOCIATED WITH ATHEROSCLEROSIS OR HYPERCHOLESTEROLEMIA | G.D. SEARLE & COMPANY | 2004-08-31 | — | — | US | disclosed |
| CN-1515567-A | Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake | G.D.ɪ����˾ | 2004-07-28 | — | — | CN | disclosed |
| US-6740663-B2 | ANTIHYPERLIPIDEMIC AGENTS | G.D. SEARLE, LLC | 2004-05-25 | — | — | US | disclosed |
| US-6387924-B2 | ATHEROSCLEROSIS; ANTICHOLESTEROL AGENTS; ANTILIPIDEMIC AGENTS | G.D. SEARLE & CO. | 2002-05-14 | — | — | US | disclosed |
| US-6268392-B1 | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors | G. D. SEARLE & CO. | 2001-07-31 | — | — | US | disclosed |
| US-6265408-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANT | SMITHKLINE BEECHAM PLC (GB) | 2001-07-24 | — | — | US | disclosed |
| US-6262277-B1 | IN MEDICINE FOR PROPHYLAXIS AND THERAPY OF HYPERLIPIDEMIC CONDITIONS SUCH AS THOSE ASSOCIATED WITH ATHEROSCLEROSIS OR HYPERCHOLESTEROLEMIA, IN MAMMALS | G.D. SEARLE AND COMPANY | 2001-07-17 | — | — | US | disclosed |
| US-5994391-A | HYPERLIPEMIC AGENTS; ANTICHOLESTEROL AGENTS | G.D. SEARLE AND COMPANY (US) | 1999-11-30 | — | — | US | disclosed |
| CN-1221414-A | Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake | SEARLE & CO (US) | 1999-06-30 | — | — | CN | disclosed |
| WO-1999011633-A1 | TRIAZINES WITH AN ADENOSINE ANTAGONISTIC EFFECT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-03-11 | — | — | WO | disclosed |
| US-5436267-A | An O-(N-2-carbamylphenyl)-heterocyclic oxime; insecticides; fungicides; miticides; nematocides; plant growth regulators; herbicides; viricides; attractants | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |