Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.39 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.39 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.39 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1289581 | 0.89 | MAOB (0.48) | MAOBHTR2AALDH1A1SLC6A3SIGMAR1 | |
| SCHEMBL7041057 | 0.82 | MAOB (0.50) | LMNARAB9AMAOBKDM4EALDH1A1 | |
| SCHEMBL6682937 | 0.81 | SIGMAR1 (0.50) | MAOBSIGMAR1 | |
| SCHEMBL7490325 | 0.81 | TAAR1 (0.48) | MAOBTAAR1 | |
| SCHEMBL6981704 | 0.80 | HTR2A (0.60) | LMNANPC1RAB9AKCNH2MAOB | |
| SCHEMBL12040571 | 0.78 | MAOB (0.58) | LMNANPC1RAB9AMAOBHTR2A | |
| SCHEMBL3334933 | 0.78 | SIGMAR1 (0.52) | MAOBHTR2AALDH1A1SLC6A3SIGMAR1 | |
| SCHEMBL364290 | 0.76 | MAOB (0.52) | MAOBHTR2AALDH1A1TAAR1SIGMAR1 | |
| SCHEMBL11365627 | 0.76 | CYP1A2 (0.49) | KMT2ASIGMAR1 | |
| SCHEMBL654154 | 0.76 | TAAR1 (0.56) | LMNANPC1RAB9AKCNH2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480984-B9 | HEXACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2009-03-11 | — | — | EP | disclosed |
| EP-1480984-B1 | CONDENSED CAMPTOTHECINS AS ANTITUMOR AGENTS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2008-06-11 | — | — | EP | disclosed |