Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.41 |
| ▸ | AOC2 | O75106 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | AGXT | P21549 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501648 | 0.90 | DRD2 (0.43) | TAAR1 | |
| SCHEMBL10667675 | 0.90 | DRD2 (0.43) | TAAR1 | |
| SCHEMBL4418035 | 0.81 | LMNA (0.45) | TAAR1MAOB | |
| SCHEMBL14880614 | 0.77 | TAAR1 (0.48) | TAAR1TRPA1MAOBIDO1LOXL2 | |
| SCHEMBL184620 | 0.77 | MAOB (0.47) | TAAR1MAOBLOXL2AOC3AOC2 | |
| SCHEMBL364290 | 0.76 | MAOB (0.52) | TAAR1MAOBLOXL2MAOA | |
| SCHEMBL7041057 | 0.74 | MAOB (0.50) | TAAR1TRPA1MAOBIDO1LOXL2 | |
| SCHEMBL11539924 | 0.74 | TAAR1 (0.50) | TAAR1TRPA1MAOBIDO1LOXL2 | |
| SCHEMBL11452249 | 0.74 | LOXL2 (0.54) | TAAR1TRPA1MAOBIDO1LOXL2 | |
| SCHEMBL65960 | 0.74 | TAAR1 (0.50) | TAAR1MAOBIDO1LOXL2AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263758-A2 | 3-(DIARYLMETHYLENE)-8-AZABICYCLO[3.2.1]OCTANE DERIVATIVES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001066543-A2 | 3-(DIARYLMETHYLENE)-8-AZABICYCLO[3.2.1]OCTANE DERIVATIVES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-09-13 | — | — | WO | disclosed |