Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 6/20 | 0.51 |
| ▸ | CES1 | P23141 | 6/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19458984 | 0.83 | CNR2 (0.50) | CES2CES1GAACNR2 | |
| SCHEMBL6491103 | 0.80 | CES2 (0.51) | CES2CES1BCHEHPGD | |
| SCHEMBL31407017 | 0.80 | CES2 (0.66) | CES2CES1BCHEALBGAA | |
| SCHEMBL1668559 | 0.80 | CES2 (0.66) | CES2CES1BCHEALBGAA | |
| SCHEMBL31407025 | 0.80 | CES2 (0.66) | CES2CES1BCHEALBGAA | |
| SCHEMBL23972274 | 0.80 | CES2 (0.66) | CES2CES1BCHEALBGAA | |
| SCHEMBL1668558 | 0.80 | CES2 (0.66) | CES2CES1BCHEALBGAA | |
| SCHEMBL27876509 | 0.79 | CES2 (0.47) | CES2CES1BCHEALBGAA | |
| SCHEMBL15920915 | 0.79 | CES2 (0.46) | CES2CES1BCHEGLSHPGD | |
| SCHEMBL3638268 | 0.78 | CES2 (0.50) | CES2CES1BCHEALBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951466-B1 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | ELAN PHARM INC (US) | 2009-01-21 | — | — | EP | disclosed |