Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.46 |
| ▸ | ANPEP | P15144 | 4/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15083833 | 0.83 | MMP2 (0.57) | MMP2ANPEPBRD4CYP1A2HIF1A | |
| SCHEMBL201253 | 0.83 | MMP2 (0.57) | MMP2ANPEPBRD4CYP1A2HIF1A | |
| SCHEMBL10269872 | 0.81 | NR1H2 (0.45) | MMP2ANPEPKMT2AALDH1A1 | |
| SCHEMBL18084470 | 0.81 | NR1H2 (0.45) | MMP2ANPEPKMT2AALDH1A1 | |
| SCHEMBL4864314 | 0.81 | NR1H2 (0.45) | MMP2ANPEPKMT2AALDH1A1 | |
| SCHEMBL5223810 | 0.80 | — | — | |
| SCHEMBL15542290 | 0.80 | — | — | |
| SCHEMBL5224593 | 0.80 | — | — | |
| SCHEMBL24635839 | 0.79 | MMP2 (0.49) | MMP2ANPEPBRD4CYP1A2HIF1A | |
| SCHEMBL13703425 | 0.79 | MMP2 (0.49) | MMP2ANPEPBRD4CYP1A2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563071-B | Chemical compounds as inhibitors of the ATF4pathway | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-08-03 | — | — | CN | disclosed |
| EP-3268356-A1 | HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE | NOVARTIS AG (CH) | 2018-01-17 | — | — | EP | disclosed |
| WO-2016142867-A1 | HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE | NOVARTIS AG (CH) | 2016-09-15 | — | — | WO | disclosed |
| EP-2049110-B1 | BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2014-08-20 | — | — | EP | disclosed |
| EP-2049110-A2 | BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008517-A2 | BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2008-01-17 | — | — | WO | disclosed |